Changes in the composition of rat liver chromatin fractions during diethylnitrosamine carcinogenesis
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چکیده
منابع مشابه
Nonhistone protein changes during the diethylnitrosamine-induced carcinogenesis of rat liver.
Diethylnitrosamine (DENA) was administered with drinking water (40 mg/liter) to male Wistar rats for 4, 6, 8, and 10 weeks. The protein:DNA ratio and the ultraviolet light spectral properties of liver chromatin were not modified by DENA treatment. Nonhistone proteins were separated by sodium dodecyl sulfate:polyacrylamide electrophoresis on slab gels and analyzed by densitometry with a scanning...
متن کاملHistochemical studies on nuclease activity and neoplastic transformation in rat liver during diethylnitrosamine carcinogenesis.
The distribution of RNase activity and the occurrence of hyperbasophilic foci and tumors have been examined in rat liver during diethylnitrosamine carcinogenesis. A focal loss of RNase activity was found to occur in the hyperplastic liver nodules prior to the development of hy perbasophilic foci and hepatomas. The RNase-negative areas were widely distributed in livers of rats treated with dieth...
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Changes in chromatin proteins during liver regeneration.
The metabolism of chromatin proteins of rat liver has been examined during the prereplicative period following partial hepatectomy. Within 8 hours after partial hepatectomy, isolated chromatin exhibits a 7% decrease in its histone to DNA mass ratio compared to sham-operated and zero time controls. The time course and amount of this decline correlate well with the previously published pattern of...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1972
ISSN: 0306-3283
DOI: 10.1042/bj1300011p